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By Dennis Thompson HealthDay Reporter
FRIDAY, Dec. 17, 2021
Why? As a result of the physique makes use of the identical set of enzymes to course of all of them, scientists report.
The chemical compounds in marijuana — THC, cannabidiol (CBD), cannabinol (CBN) — are metabolized within the physique by at the very least two households of enzymes that additionally assist course of and get rid of greater than 70% of essentially the most generally used prescription drugs from the physique, the researchers mentioned.
Meaning there is a threat that pot would possibly dangerously amp up the results of some prescription drugs, or trigger different drugs to flush by your system so shortly that they do you no good, mentioned lead researcher Philip Lazarus. He is a professor of pharmaceutical sciences at Washington State College, in Spokane.
“We noticed some vital inhibitions,” Lazarus mentioned. “The concentrations we see within the lab are most likely an indicator there may be at the very least some inhibition of those enzymes in real-time.”
Some medication that might be affected by pot use embrace the blood thinner warfarin, the breast cancer drug tamoxifen, and painkillers like acetaminophen (Tylenol) or ibuprofen (Motrin), mentioned Lazarus and Ed Bednarczyk, a medical affiliate professor of pharmacy apply on the College at Buffalo, in New York.
In two lab reviews revealed within the December difficulty of the journal Drug Metabolism and Disposition, Lazarus served as senior creator. One examine checked out a household of enzymes often called cytochrome P450s (CYPs), and the opposite analyzed the enzyme group UDP-glucuronosyltransferases (UGTs).
The CYPs are concerned within the early phases of metabolizing THC and CBD, whereas the UGTs are concerned within the later phases.
THC and CBD keep in your physique for under about half-hour earlier than the enzymes break them down, however the chemical compounds that end result from the method can linger in your physique for as much as two weeks, the examine authors mentioned in background notes.
Within the lab, the researchers examined how the pot chemical compounds would possibly intervene with these enzymes’ skill to interrupt down different medication, utilizing cultured human kidney cells to check a single enzyme at a time.
The investigators discovered that the main THC metabolites inhibited key CYP enzymes, together with a number of that serve key roles within the liver.
And all three hashish chemical compounds, however particularly CBD, inhibited two of the first UGT enzymes within the liver.
CBD was additionally discovered to dam three enzymes that account for about 95% of UGT metabolism within the kidney, which helps clear toxins and a few medication from the physique.
CBD, THC block enzymes that break down different meds
“It is a very, superb reminder that these interactions are actual,” Bednarczyk mentioned. “It is essential for physicians and pharmacists who’re working with sufferers to discover this.”
That is the primary analysis effort to display the potential results of pot on UGT enzymes, the researchers mentioned. The examine additionally sheds extra gentle on marijuana‘s impact on CYP enzymes.
It has been recognized for a while that pot might work together with different medication, mentioned Paul Armentano, deputy director of NORML, a gaggle that advocates for the reform of marijuana legal guidelines.
The U.S. Meals and Drug Administration’s labeling of a type of artificial THC known as dronabinol, which has been out there as a prescription drug for greater than 30 years, signifies that it’d affect CYP ranges, Armentano famous. And the company’s warning for Epidiolex, a plant-based prescription CBD drug, additionally addresses how the substance might have an effect on the liver, he added.
However Armentano questioned how highly effective these interactions might be, given how lengthy marijuana has been used each recreationally and medicinally.
“Adults — and sufferers particularly — have been consuming cannabinoids medicinally for hundreds of years, and this apply has grow to be fairly commonplace over the previous few a long time,” Armentano mentioned. “Many of those sufferers are older and lots of of them may be prescribed different drugs. Had been cannabinoids to be considerably contraindicated amongst this inhabitants, one would presume that there can be ample empirical proof already out there substantiating this concern.”
Pot’s impact on metabolism would not probably have an effect on somebody who takes a leisure toke or three on the weekend, Lazarus mentioned.
“Although it most likely inhibits these enzymes, it would not inhibit them sufficient to intervene along with your on a regular basis metabolism,” Lazarus acknowledged.
The issue comes once you combine common pot use with different medication, or when you’re taking a marijuana-derived product alongside your prescription.
“Usually,” Bednarczyk mentioned, “CBD is believed to inhibit metabolic pathways, and THC is believed to induce metabolic pathways. THC could make your blood ranges of different medication fall, and CBD could make your blood ranges rise.”
Warfarin, CBD a harmful combo
One well-known instance is warfarin, “a really, very potent blood thinner,” Bednarczyk mentioned.
A case examine revealed a few years in the past famous one warfarin affected person who “had the results of this drug go means up into the hazard zone shortly after beginning CBD,” Bednarczyk mentioned. “That one, you do not mess with. The consequences of getting too excessive a degree even transiently for a couple of days will be deadly,” he warned.
“That is the king of the hill for threat, as a result of it is everywhere in the map by way of patient-to-patient variability,” Bednarczyk mentioned of warfarin and pot. “One affected person can want a bucket of these items to have the identical impact as one other affected person who’s on the bottom dose manufactured.”
For tamoxifen to work, he famous, it have to be damaged down by the physique into one other chemical known as endoxifen, which is 100 instances extra energetic than tamoxifen.
If pot interferes with the processing of tamoxifen, it might trigger the breast cancer affected person to obtain little to no profit from the drug, Lazarus defined.
Ibuprofen “is poisonous to your liver and your kidney anyway, however you begin taking marijuana on prime of that, then you are going to see some vital results,” Lazarus mentioned. “It might most likely trigger toxicity since you’re slowing down its metabolism, so meaning you are not excreting the stuff and you’ve got extra of it sitting in your physique.”
Nonetheless, all these issues are based mostly on lab research. What’s wanted now are clinical trials to determine the true results of pot on different medication, Lazarus famous.
“We’ve got to do some medical research to point out in those who when you’re taking a selected drug and then you definitely additionally smoke a marijuana cigarette that morning, you see greater or decrease ranges of that drug in your physique,” Lazarus mentioned.
Within the meantime, individuals ought to talk about their use of pot merchandise with their physician and their pharmacist to ensure they don’t seem to be placing their well being in danger, Lazarus and Bednarczyk mentioned.
“This shouldn’t be a roll-your-own course of,” Bednarczyk mentioned.
The Mayo Clinic has extra on possible drug interactions with marijuana.
SOURCES: Philip Lazarus, PhD, professor, pharmaceutical sciences, Washington State College, Spokane, Wash.; Ed Bednarczyk, PharmD, medical affiliate professor, pharmacy apply, College at Buffalo, New York; Paul Armentano, deputy director, NORML, Washington, D.C.; Drug Metabolism and Disposition, Dec. 13, 2021
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