Lipitor Statin (Atorvastatin) Side Effects, Uses, & Dosage

0 0
Read Time:3 Minute, 56 Second


What’s Lipitor (atorvastatin), and what’s it used for?

Model identify: Lipitor
Generic identify: atorvastatin
Dosage varieties: pill (10 mg)
Drug class: statins, HMG-CoA reductase inhibitors, lipid-lowering brokers

Lipitor (atorvastatin) is sort of statin that lowers the extent of cholesterol within the blood. All statins, together with atorvastatin, stop the manufacturing of ldl cholesterol within the liver by blocking HMG-CoA reductase, an enzyme that makes ldl cholesterol. Statins scale back whole ldl cholesterol in addition to LDL cholesterol in blood.

LDL cholesterol is believed to be the “unhealthy” ldl cholesterol that’s primarily answerable for the event of coronary artery disease. Decreasing LDL cholesterol levels retards development and will even reverse coronary artery disease. Atorvastatin additionally raises the concentrations of HDL (“good”) ldl cholesterol that protects towards coronary artery illness and reduces the focus of triglycerides within the blood. (Excessive blood concentrations of triglycerides even have been related to coronary artery illness.)

Examples of different statins embody:

Lipitor (atorvastatin) makes use of

Lipitor is used for the therapy of elevated whole ldl cholesterol, LDL, and triglycerides, and to raise HDL cholesterol. The effectiveness of Lipitor in lowering cholesterol is dose-related, that means that greater doses scale back ldl cholesterol extra.

In people with coronary artery illness Lipitor prevents:

Lipitor reduces the danger of heart assault, stroke, angina, and revascularization procedures in adults with out proof of coronary heart disease, however with a number of danger components for coronary artery illness, for instance:

What are the uncomfortable side effects of atorvastatin?

Lipitor (atorvastatin) is usually effectively tolerated. Minor uncomfortable side effects embody:

Different generally reported uncomfortable side effects embody:

Lipitor might trigger liver and muscle injury. Critical liver injury brought on by statins is uncommon. Liver tests must be carried out firstly of therapy then as wanted thereafter.

Irritation of the muscular tissues brought on by statins can result in critical breakdown of muscle cells known as rhabdomyolysis. Rhabdomyolysis causes the discharge of muscle protein (myoglobin) into the blood, and myoglobin could cause kidney failure and even dying. When used alone, statins trigger rhabdomyolysis in lower than one p.c of sufferers. To forestall the event of great rhabdomyolysis, sufferers taking atorvastatin ought to contact their health-care skilled instantly in the event that they develop unexplained muscle pain, weakness, or muscle tenderness.

Statins have been related to will increase in HbA1c and fasting serum glucose ranges as seen in diabetes.

Publish-marketing reviews for atorvastatin of hostile occasions embody:

Signs might begin someday to years after beginning therapy and resolve inside a median of three weeks after stopping the statin.

What’s the dosage for atorvastatin?

Lipitor is prescribed as soon as every day.
The standard beginning dose for adults is 10-20 mg per day, and the utmost dose is 80 mg per day. Adults who want greater than a forty five% discount in LDL cholesterol could also be began at 40 mg every day.
Pediatric sufferers ought to obtain 10 mg as soon as every day as much as a most dose of 20 mg every day.
Lipitor could also be taken with or with out meals and at any time of day.

SLIDESHOW

How to Lower Your Cholesterol & Save Your Heart
See Slideshow

What medication work together with atorvastatin?

Decreased elimination of Lipitor might improve ranges of Lipitor within the physique and improve the danger of muscle toxicity from Lipitor. Subsequently, Lipitor shouldn’t be mixed with drugs that lower its elimination. Examples of such medication contains:

Massive portions of grape fruit juice (>1.2 liters every day) additionally will improve blood ranges of Lipitor and shouldn’t be taken.

The next medication additionally might improve the danger of muscle toxicity when mixed with Lipitor.

Lipitor will increase the impact of warfarin and the focus in blood of digoxin (Lanoxin). Sufferers taking Lipitor and warfarin or digoxin must be monitored fastidiously. Cholestyramine decreases the absorption of Lipitor. Lipitor must be given not less than two hours earlier than and not less than 4 hours after cholestyramine.

Rifampin will increase breakdown of Lipitor. To cut back the probability of this interplay each medication must be given on the similar time. Lipitor shouldn’t be given after rifampin.

Is atorvastatin protected to make use of throughout being pregnant or whereas breastfeeding?

Lipitor might trigger fetal hurt when administered to a pregnant girl. Lipitor must be discontinued as quickly as pregnancy is acknowledged. Lipitor ought to solely be administered to ladies of childbearing age if they aren’t more likely to develop into pregnant.
It isn’t recognized if Lipitor is secreted in breast milk. Due to the potential danger of hostile occasions, breastfeeding moms mustn’t use Lipitor.

Medically Reviewed on 12/8/2021
References

FDA Prescribing Data

Happy
Happy
0 %
Sad
Sad
0 %
Excited
Excited
0 %
Sleepy
Sleepy
0 %
Angry
Angry
0 %
Surprise
Surprise
0 %

Average Rating

5 Star
0%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%